1．研究生导师的基本情况

姓名

刘伟

性别

男

职称

教授

最高学位

博士

毕业院校

哈尔滨医科大学

专业学科类别

数学

研究方向

生物信息学（方向）生物大数据挖掘（方向）

Email

freelw@qq.com

2．个人简介

从事生物信息数据挖掘和生物信息学算法开发等方面的研究，在癌症精确分类、生存风险预测、biomarker识别、通路网络分析、风险通路识别等方面做出了显著工作。主持国家自然科学基金青年科学基金，中国博士后科研基金，黑龙江省自然科学基金，黑龙江省创新人才培养计划等项目。开发了癌症精确分类软件包“DRWPClass”、“DRWPClassGM”，生存风险预测软件包“PCLasso”、“RLassoCox”、“RPCR”、“DRWPSurv”、“RRSF”，以及差异共表达网络识别软件包“DCN”等多个R软件包，分类预测性能达到国际先进水平，被国内外多个研究机构和学者所引用。发表SCI论文近20篇（累计SCI-IF=118.65），其中第一作者或第一通讯作者11篇（JCR一区7篇），发表在《Nature communications》（JCR一区，SCI-IF/5年=15.805）、《Briefings in Bioinformatics》（JCR一区，SCI-IF/5年=10.288）、《Bioinformatics》（JCR一区，SCI-IF/5年=8.470，2篇）、《British Journal of Cancer》（JCR一区，SCI-IF/5年=7.570）等国际主流专业期刊杂志上。

3．主持或参与完成的科技项目(或负责的重点、重大工程项目)

（1）国家自然科学基金青年科学基金项目，61602292，食管癌中关键ncRNA细胞功能调控模块识别及其分子机制研究，2017/01-2019/12，已结题，主持。

（2）中国博士后科学基金面上项目，2016M602499，食管癌中关键ncRNA细胞功能调控模块识别及机制研究，2016/09-2019/09，已结题，主持。

（3）黑龙江省普通本科高等学校青年创新人才培养计划，UNPYSCT-2016102，融合多组学和通路拓扑结构信息的癌症精确分类算法研究，2016/06-2019/06，已结题，主持。

（4）黑龙江省教育厅科学技术项目，12541684，基于随机游走的通路拓扑结构信息挖掘及其在疾病精确分类中的应用，2014/01-2016/12，已结题，主持。

（5）黑龙江工程学院青年科学基金，2013QJ14，基于随机游走的通路拓扑结构信息挖掘及其在疾病精确分类中的应用，2013/07-2015/07，已结题，主持。

（6）黑龙江工程学院博士科学基金，2015BJ16，整合高通量基因、代谢子和通路拓扑信息挖掘风险代谢通路及癌症精确分类，2015/01-2021/10，已结题，主持。

4．目前承担(或参与)的在研科技项目或重点工程项目

（1）黑龙江省省属本科高校基本科研业务费国家基金培育专项，2021GJ09，基于大规模和高分辨率质谱的食管鳞癌蛋白组学分析与新亚型识别研究，2022/01-2024/12，在研，主持。

（2）黑龙江省自然科学基金项目，LH2021F048，基于蛋白组学的食管鳞癌亚型识别与药物预测研究，2021/07-2024/07，在研，主持。

5．发表的代表性论文及著作

（1）Wei Liu, Yongping Cui, Wen Liu, Zhihua Liu, Liyan Xu, Enmin Li. Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma. Cancer Biol Med. 2022,19(3):273–7.

（2）Wei Liu#, Lei Xie# Yao-Hui He#, Zhi-Yong Wu#, Lu-Xin Liu#, Xue-Feng Bai, Dan-Xia Deng, Xiu-E Xu, Lian-Di Liao, Wan Lin, Jing-Hua Heng, Xin Xu, Liu Pen , Qing-Feng Huang, Cheng-Yu Li, Zhi-Da Zhang, Wei Wang, Guo-Rui Zhang, Xiang Gao, Shao-Hong Wang, Chun-Quan Li, Li-Yan Xu, Wen Liu, En-Min Li. Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting. Nat Commun, 2021. 12(1): p. 4961.

（3）Wang, W. and Wei Liu*, PCLasso: a protein complex-based, group lasso-Cox model for accurate prognosis and risk protein complex discovery. Brief Bioinform, 2021. 22(6): bbab212.

（4）Wei Wang, Wei Liu*, Integration of gene interaction information into a reweighted Lasso-Cox model for accurate survival prediction, Bioinformatics, 2020. 36(22-23): 5405-5414.

（5）Wei Liu#, Cai‐Yan Gan#, Wei Wang, Lian‐Di Liao, Chun‐Quan Li, Li‐Yan Xu*, En‐Min Li*. Identification of lncRNA-associated differential subnetworks in oesophageal squamous cell carcinoma by differential co-expression analysis. J Cell Mol Med. 2020. 24(8):4804-4818.

（6）Meng Li#, Jianmei Zhao#, Xuecang Li#, Yang Chen, Chenchen Feng, Fengcui Qian, Yuejuan Liu, Jian Zhang, Jianzhong He, Bo Ai, Ziyu Ning, Wei Liu, Xuefeng Bai, Xiaole Han, Zhiyong Wu, Xiue Xu, Zhidong Tang, Qi Pan, Liyan Xu, Chunquan Li*, Qiuyu Wang*, Enmin Li*. HiFreSP: A novel high-frequency sub-pathway mining approach to identify robust prognostic gene signatures. Brief Bioinform, 2020. 21(4): p. 1411-1424.

（7）Wei Wang and Wei Liu*. Integration of gene interaction information into a reweighted random survival forest approach for accurate survival prediction and survival biomarker discovery. Scientific Reports. 2018. 8(1): p. 13202.

（8）Wei Liu#, Jianzhong He#, Shaohong Wang, Dekai Liu, Xuefeng Bai, Xiue Xu, Jianyi Wu, Yong Jiang, Chunquan Li, Longqi Chen, Enmin Li* and Liyan Xu*. MASAN: a novel staging system for prognosis of patients with oesophageal squamous cell carcinoma. British Journal of Cancer, 2018, 118(11): 1476-1484.

（9）Wei Liu#, Wei Wang#, Guohua Tian, WenmingXie, Li Lei, Jiujin Liu, Wanxun Huang, Liyan Xu* and Enmin Li*. Topologically inferring pathway activity for precise survival outcome prediction: breast cancer as a case. Molecular Biosystems, 2017, 13(3):537-548.

（10）Wei Liu#, Chunquan Li#, Yanjun Xu, Haixiu Yang, Qianlan Yao, Junwei Han, Desi Shang, Chunlong Zhang, Fei Su, Xiaoxi Li, Yun Xiao, Fan Zhang, Meng Dai*, Xia Li*. Topologically inferring risk-active pathways toward precise cancer classification by directed random walk. Bioinformatics, 29(17): 2169-77, 2013.

（11）Wei Liu #, Xuefeng Bai#, Yuejuan Liu#, Wei Wang, Junwei Han, Qiuyu Wang, Yanjun Xu, Chunlong Zhang, Shihua Zhang, Xuecang Li, Zhonggui Ren, Jian Zhang and Chunquan Li. Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case. Scientific Reports, 2015,5: 13192.

（12）Wei Liu#, Qiuyu Wang#, Jianmei Zhao, Chunlong Zhang, Yuejuan Liu, Jian Zhang, Xuefeng Bai, Xuecang Li, Houming Feng, Mingzhi Liao, Wei Wang* and Chunquan Li*. Integration of pathway structure information into a reweighted partial Cox regression approach for survival analysis on high-dimensional gene expression data. Molecular BioSystems, 2015, 11:1876-1886.

（13）Ziyu Ning#, Chenchen Feng#, Chao Song#, Wei Liu, Desi Shang, Meng Li, Qiuyu Wang, Jianmei Zhao, Yuejuan Liu, Jiaxin Chen, Xiaoyang Yu, Jian Zhang, Chunquan Li*. Topologically inferring active miRNA-mediated subpathways toward precise cancer classification by directed random walk. Molecular oncology 2019, 13, 2211-2226.

（14）Jian-mei Zhao , Xuecang Li , Qianlan Yao , Meng Li , Jian Zhang , Bo Ai , Wei Liu , Qiuyu Wang , Chenchen Feng , Yuejuan Liu , Xuefeng Bai , Chao Song , Shang Li , enmin li , Liyan Xu. RWCFusion: Identifying phenotype-specific cancer driver gene fusions based on fusion pair random walk scoring method. Oncotarget, 2016, 7(38):61054-61068.

（15）Jing Li, Chunquan Li, Junwei Han, Chunlong Zhang, Desi Shang, Qianlan Yao, Yunpeng Zhang, Yanjun Xu, Wei Liu, Meng Zhou, Haixiu Yang, Fei Su, Xia Li*. The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure. Journal of Biomedical Informatics, Feb 21, 2014.

（16）Junwei Han#, Chunquan Li#, Haixiu Yang#, Yanjun Xu, Chunlong Zhang, Jiquan Ma, Xinrui Shi, Wei Liu, Desi Shang, Qianlan Yao, Yunpeng Zhang, Fei Su, Li Feng and Xia Li*. A novel dysregulated pathway-identification analysis based on global influence of within-pathway effects and crosstalk between pathways. J. R. Soc. Interface 12 : 20140937, 2014.

（17）Jian Zhang#, Yan Wang#, Desi Shang#, Fulong Yu, Wei Liu, Yan Zhang, Chenchen Feng, Qiuyu Wang, Yanjun Xu, Yuejuan Liu, Xuefeng Bai, Xuecang Li, Chunquan Li*. Characterizing and optimizing human anticancer drug targets based on topological properties in the context of biological pathways. Journal of Biomedical Informatics, 2015, doi: 10.1016/j.jbi.2015.02.007.

（18）Yunpeng Zhang, Wei Liu, Yanjun Xu, Chunquan Li, Yingying Wang, Haixiu Yang, Chunlong Zhang, Fei Su, Yixue Li* and Xia Li*. Identification of subtype specific miRNA-mRNA functional regulatory modules in matched miRNA-mRNA expression data: multiple myeloma as a case. BioMed Research International, 2014: 501262.

（19）Feng Li, Yanjun Xu, Desi Shang, Haixiu Yang, Wei Liu, Junwei Han, Zeguo Sun, Qianlan Yao, Chunlong Zhang, Jiquan Ma, Fei Su, Li Feng, Xinrui Shi, Yunpeng Zhang, Jing Li, Qi Gu, Chunquan Li*, and X. Li*. MPINet: metabolite pathway identification via coupling of global metabolite network structure and metabolomic profile. BioMed Research International, 2014: 325697, doi: 10.1155/2014/325697, PubMed PMID: 25057481.

6．科技成果及奖励(包括专利、工法、工程奖)

?